8 Appendices

Appendix I Appendix II Appendix III Appendix IV Appendix V


Appendix II

Source: Locatelli F, Valderrabano F, Heonich N, Bommer J, Leunissen K, Cambi V.
Progress in dialysis technology: membrane selection and patient outcome. Nephrol Dial Transplant (2000)
15: 1133-1139.

Note: these data were taken from the following sources for the year 1998: European dialysis and Transplant Association (EDTA) returns, Perilon database, The Registratie Nierfuncievervanging Nederland (RENINE), Membrana GmbH market research report. In 1998 only the Netherlands had a comprehensive national renal registry covering the whole country. The UK Renal Registry now covers over 50% of the country and will shortly be able to provide accurate prevalence data. Meanwhile the figures quoted here should be taken as an approximate guide. The comments are from the above authors.

 
Germany
pop 81.7 million
No. of Patients
(% total)
Prevalence
pmp
Acceptance
pmp.pa
 
 
Transplant 15,441 (24%) 189 30

Dialysis (All)

49,239 (76%) 602 162
HD 45,766 (71%) 560 145
PD 3,473 (5%) 40 17
All ESRF 64,640 (100%) 791 162*
 

Germany has the highest number of patients under treatment for ESRF in Europe. This is mainly due to the very large population of HD patients, supported with a strong transplantation sector, although the proportion of PD patients remains low at 5%. The number of new patients remains high for both HD and transplantation.

 
Netherlands
pop 15.5 million
No. of Patients
(% total)
Prevalence
pmp
Acceptance
pmp.pa
 
 
Transplant 4,290 (50%) 277 29

Dialysis (All)

4299 (50%) 273 81
HD 3,053 (36%) 197 57
PD 1,246 (14%) 80 24
All ESRF 8,589 (100%) 554 81*
 

Statistics for ESRF treatment are carefully documented in the Netherlands. The overall treatment rate is relatively low. Transplantation plays the largest part, although the new patient rate is only average.
The PD sector is proportionately larger. HD has not developed as far as might be anticipated. Regulations do not allow private sector dialysis facilities.

 
UK
pop 58.6 million
No. of Patients
(% total)
Prevalence
pmp
Acceptance
pmp.pa
 
 
Transplant 15,689 (24%) 268 25

Dialysis (All)

13,484 (46%) 230 87
HD 8,162 (28%) 139 55
PD 5,322 (18%) 91 32
All ESRF 29,173 (100%) 498 87*
 

The UK was one of the forerunners in Europe of ESRD treatment. However, in recent years there has been a lack of resources devoted to the therapy and thus, inadequate treatment rates have been noted.
The previous high transplantation rate has decreased to below average. The HD sector has been neglected in favour of PD which until recently accounted for half of the patients on chronic dialysis. However, lack of long-term adequacy of PD has prompted an increase in HD facilities, although the number of new patients is still relatively low.


 
Spain
pop 39.1 million
No. of Patients
(% total)
Prevalence
pmp
Acceptance
pmp.pa
 
 
Transplant 11,142 (39%) 285 45

Dialysis (All)

17,804 (61%) 456 120
HD 16,327 (56%) 418 104
PD 1,477 (5%) 38 16
All ESRF 28,946 (100%) 741 120*
 

Spain has increased the treatment of ESRF in recent years and overall treatment and new patient rates are relatively high. Most notable is the large number of transplant patients and the continuing high number of new patients of 45 pmp, a result of the conscious decision some years ago to concentrate on organ replacement. HD therapy has been developed and the new patient rate is now similar to that in Italy.

 
Italy
pop 57.7 million
No. of Patients
(% total)
Prevalence
pmp
Acceptance
pmp.pa
 
 
Transplant 9,856 (20%) 171 24

Dialysis (All)

39,417 (80%) 683 130
HD 34,214 (69%) 593 104
PD 5,203 (11%) 90 26
All ESRF 49,273 (100%) 854 130*
 

The overall treatment rate (prevalence) in Italy for ESRD is the highest in Europe, mainly due to a high concentration on HD (at 593 pmp, this is even higher than that of Germany). This is augmented by a PD penetration rate of 11%. Whilst the transplantation rate is lower than average, the PD sector is more developed.

 
France
pop 81.7 million
No. of Patients
(% total)
Prevalence
pmp
Acceptance
pmp.pa
 
 
Transplant 12,255 (33%) 211 28

Dialysis (All)

24,553 (67%) 423 111
HD 21,950 (60%) 378 89
PD 2,603 (7%) 45 22
All ESRF 36,808 (100%) 634 111*
 

France has a fairly high overall treatment rate of 634 pmp, predominantly from the HD sector. The overall new patient rate is not particularly high at 111 pmp For HD, the new patient rate is 89 pmp, significantly lower than in both Spain and Italy. The transplantation rate is now only 28 pmp.

 
 
Germany, Netherlands, Spain,
Italy, France Pop 252.1 million

UK
Pop 58.6 million

 
 
  Patient No.
(% total)

Prevalence
PMP

Patient No.
(% total)
Prevalence
PMP
Transplant 52,984 (28%) 210 15,689 (54%) 268
Dialysis (All)

135,312 (72%)

537 13,484 (46%) 230
HD 121,310 (64%) 481 8,162 (28%) 139
PD 14,002 (8%) 56 5,322 (18%) 91
All ESRF 188,296 (100%) 747 29,173 (100%) 498
 

* To avoid double counting, acceptance for all ESRF includes only those taken onto dialysis since the majority of new transplants are accepted onto dialysis first